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Adrenaline – significance, function, deficiency, excess

30 września 2022
adrenaline, epinephrine, stress hormone, hypo-adrenalism, hyper-adrenalism, adrenaline deficiency, excess adrenaline
Adrenaline, also known as epinephrine, is another hormone discussed by experts collaborating with the Polish company ONSEN® in response to numerous requests from readers of the best health blog submitted in various forms.

As with nearly every hormone, even the slightest disruption in adrenaline levels can lead to a disruption of the hormonal system as a whole. This system is responsible for biopsychosocial functioning during the day and night.

It is therefore important to understand what adrenaline is, but also to be aware of its effects. It is also necessary to know what the risks of adrenaline deficiency or excess are, so as to be able to recognize potential symptoms of illness at an early stage.
adrenaline, epinephrine, stress hormone, hypo-adrenalism, hyper-adrenalism, adrenaline deficiency, excess adrenaline

What is the significance of adrenaline?

Adrenaline is called the hormone of fear, fight, and flight, as it is a key neurotransmitter produced by the adrenal glands. Its main task is to mobilize the body to quickly respond in stressful and dangerous situations. An increase in adrenaline levels in the blood allows for rapid adaptation to changing conditions, influencing heart activity, metabolism, and the functioning of the nervous system.

Norepinephrine, which belongs to the catecholamine group, is produced directly in the adrenal medulla in response to stress stimuli. It stimulates the sympathetic nervous system, triggering a series of physiological reactions. Their main purpose is to prepare the body for exertion, especially intense exertion.

As a result of adrenaline's action, the body accelerates the heart rate. This, in turn, is associated with an increase in blood pressure and dilation of the bronchi, improving oxygen supply. Epinephrine also causes mobilization of glucose from the liver, allowing it to be delivered to the muscles. In addition, it constricts blood vessels in the digestive organs to redirect blood to the muscles at the expense of digestion processes. All this causes an increase in concentration and alertness, helping to react more quickly to threats.

Although adrenaline is mainly associated with stressful situations, the level of epinephrine also rises during moments of euphoria and strong emotions, regardless of their cause. This can be the result of intense physical effort or excitement, but also experiencing other events. For this reason, adrenaline is also called the hormone of excitement.

In principle, the proper concentration of adrenaline in the blood serum of adults should be from 240 pmol/l to 480 pmol/l, i.e., from 43.92 pg/ml to 87.84 pg/ml. However, it is worth noting that adrenaline levels can vary depending on the conditions of the study.

adrenaline, epinephrine, stress hormone, hypo-adrenalism, hyper-adrenalism, adrenaline deficiency, excess adrenaline

How does adrenaline work?

Adrenaline is a catecholamine hormone and neurotransmitter secreted by the adrenal medulla, which is part of the endocrine system. Although the adrenal cortex is often mentioned, it is actually the adrenal medulla that is responsible for the synthesis of adrenaline. Additionally, adrenaline is also secreted by the endings of sympathetic nervous system fibers, making this hormone one of the fundamental transmitters responsible for mobilizing the body in stressful situations, and not only.

It is chemically similar to pyrocatechol (catechol). Moreover, its secretion can be stimulated by testosterone, which means that individuals with higher levels of this hormone may show a greater tendency for adrenergic reactions, thus intense emotions or a propensity to take risks.

Epinephrine plays an important role in regulating glucose metabolism, acting antagonistically towards insulin, thus combating it. This means that adrenaline lowers insulin levels in the blood, leading to increased blood sugar levels, providing the body with additional energy in stressful situations. Besides, adrenaline stimulates the secretion of glucagon, causing the release of glucose from the liver into the bloodstream.

Adrenaline acts on α-adrenergic and β-adrenergic receptors, which are responsible for activating the sympathetic system. This leads to an acceleration of heart rate and dilation of the bronchi, and consequently, to an increased blood flow to the muscles. A similar effect is shown by norepinephrine, however, unlike adrenaline, it does not significantly affect metabolism, having little impact on digestion.

The most important effect of adrenaline action is the acceleration of heart activity and an increase in its cardiac output, which improves the transport of oxygen and nutrients to the body's tissues. Additionally, epinephrine causes dilation of the pupils, which enhances visual acuity. It also causes dilation of the larynx and bronchi, improving oxygen supply to the lungs. In turn, increasing the rate of breathing facilitates oxygenation of the body.

Adrenaline also has a significant impact on metabolism, as it activates lipases, enzymes responsible for burning fat, which aids in the reduction of fat tissue. For this reason, it is a hormone that supports metabolic processes, and thus is sometimes used in the symptomatic treatment of some metabolic disorders.

Additionally, adrenaline stimulates the secretion of saliva and digestive juices, which also affects digestion. Besides, epinephrine reduces the tension of smooth muscles in the abdominal cavity. However, in stressful situations, adrenaline inhibits intestinal peristalsis, which slows digestion.
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What is associated with a deficiency of adrenaline?

Adrenaline plays a key role in regulating bodily functions, which is why its deficiency can lead to serious health consequences. Low adrenaline levels are most commonly caused by adrenal gland disorders, but they can also result from hormonal imbalances in other glands that are linked to them.

Causes of Adrenaline Deficiency

As a rule, adrenaline deficiency is usually associated with dysfunction of the endocrine system, particularly the adrenal glands, which produce it. The most commonly reported causes of low epinephrine levels include:

  • adrenal insufficiency – a condition in which the adrenal glands do not produce enough adrenaline and other hormones;
  • adrenal tumors – certain tumors can disrupt adrenal gland function and affect their ability to synthesize catecholamines;
  • genetic disorders – some inherited diseases can lead to abnormalities in adrenaline production, affecting the body's hormonal balance.

Effects of Adrenaline Deficiency

Persistently low adrenaline levels can lead to a range of symptoms affecting daily life. The most common effects of adrenaline deficiency include:

  • tachycardia – an increased heart rate resulting from the body's compensatory mechanisms;
  • hypotension – low blood pressure, which can cause dizziness and weakness;
  • chronic fatigue – adrenaline deficiency contributes to a lack of energy and a constant feeling of exhaustion;
  • difficulty concentrating – problems with memory and focus;
  • weight gain – a slowed metabolism, which can lead to weight increase;
  • mood disorders – emotional fluctuations, feelings of apathy or anxiety;
  • sleep disturbances – difficulty falling asleep or restless sleep.

Adrenaline deficiency is a dangerous condition that can significantly impact quality of life, directly leading to body weakness, circulatory problems, and mood disorders. If symptoms indicating a low adrenaline level occur, it is essential to consult a doctor.

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What is associated with an excess of adrenaline?

Adrenaline plays a crucial role in the body's response to stress. However, when there is an excess of epinephrine in the body, it can lead to various health issues. High adrenaline levels can be caused by chronic stress, certain medical conditions, or a life full of tension.

Causes of Excess Adrenaline

In general, excess adrenaline can result from various physiological and environmental factors. The most significant include:

  • chronic stress – constant tension and stress can lead to increased adrenaline secretion;
  • hormonal disorders – such as catecholamine-producing tumors (pheochromocytoma), which increase adrenaline production;
  • lifestyle – excessive physical activity or lack of rest can also contribute to high adrenaline levels.

Effects of Excess Adrenaline

An excessive amount of adrenaline can lead to various undesirable effects, including:

  • heart problems – tachycardia or even a heart attack caused by constant tension in the heart muscle;
  • sleep disturbances – difficulty falling asleep, restless sleep;
  • high blood pressure – increased risk of cardiovascular diseases;
  • mental health disorders – anxiety, panic attacks, or even depression caused by chronic stress;
  • fatigue – paradoxically, despite increased activity, the body may feel exhausted;
  • metabolic disorders – increased blood sugar levels and difficulties with metabolism.

In the case of excess adrenaline, it is important to take steps to mitigate its negative effects. Reducing stress and ensuring proper rest can help, unless medical intervention is necessary.

If you notice symptoms of excess adrenaline, it is essential to consult a doctor who can determine the cause of the condition and recommend appropriate treatment.

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How does adrenaline affect sleep?

Our psychologist, Mateusz Nesterok, a specialist in health psychology and rehabilitation, highlights the importance of maintaining an optimal adrenaline level in the body. While this hormone plays a key role in daily functioning, its excess can lead to serious health consequences. An excessively high adrenaline level is associated with hypertension and dizziness, as well as anxiety disorders and psychosomatic depression. Its impact on sleep is also significant, as an excess of epinephrine in the blood can cause insomnia and lower sleep quality.

He also points out that a low adrenaline level is not beneficial either. Although it is rare, it is important to remember that an adrenaline deficiency can lead to decreased concentration and weakened cognitive functions. It can also hinder weight loss and even promote weight gain. Any disruption of hormonal balance has a significant impact on human functioning.

As scientific research proves, maintaining an adequate amount of sleep at night helps lower adrenaline levels in the blood. This demonstrates that adrenaline is strongly related to the sleep-wake cycle, making it essential to maintain proper levels. Moreover, research results indicate that reducing adrenaline concentration in the blood lowers body temperature and reduces fatigue.

To ensure proper body regeneration, it is crucial to focus on comfortable sleep, which effectively supports hormonal balance on multiple levels. A key element is a truly comfortable mattress, which also provides proper body support and relieves the spine. Only in this way can the body fully relax, positively affecting the hormonal system.

ONSEN® offers the Osaka Air mattress, which is the most functional mattress available. This product meets the needs and solves the problems of even the most demanding individuals. Additionally, it comes with an up to 15-year warranty, thanks to the use of high-quality materials. Moreover, the Osaka Air mattress can be returned within 100 days without consequences, so you take no risk.

We also encourage you to explore other articles on the best sleep and health blog, as well as the Encyclopedia of Healthy Sleep prepared by the ONSEN® team of specialists. For those who care about spine health, we recommend a set of spine exercises prepared by our physiotherapist.

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FAQ: Adrenaline

What is adrenaline responsible for?

Adrenaline is responsible for the body's proper response in dangerous situations. That is why it is often called the hormone of fear, fight, and flight. Additionally, adrenaline is produced during states of euphoria.

What are the effects of adrenaline deficiency or low levels?

The primary effect of adrenaline deficiency or low levels is tachycardia. Additionally, a lack of adrenaline can lead to low blood pressure and chronic fatigue. Low adrenaline levels also cause difficulties with weight loss but, most importantly, severe mood and sleep disorders.

What are the effects of excess or high levels of adrenaline?

The primary effect of excess or high levels of adrenaline is bradycardia. Additionally, high adrenaline levels can cause high blood pressure, dizziness, and vision disturbances. It also triggers unnecessary anxiety. People with excessive adrenaline often experience physical and mental exhaustion. Furthermore, adrenaline contributes to anxiety disorders, mood disorders, and difficulties in falling and staying asleep.

How to increase adrenaline production?

Adrenaline production can be increased through physical activity and experiencing more states of euphoria. Additionally, certain medications can stimulate adrenaline release.

How to decrease adrenaline production?

Adrenaline production can be reduced by leading a calm lifestyle and avoiding stress. Moreover, adrenaline levels decrease with the release of endorphins, so it is beneficial to be happier. Lowering adrenaline levels in the blood can also be achieved through sex and a proper diet.

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