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BLOG ONSEN® / About health

Estradiol (E2) – meaning, function, deficiency, excess

6 września 2020
Estradiol, E2, estrogens, ovaries, libido, excess of estradiol, deficiency of estradiol
Contents
Estradiol (E2) – meaning
Estradiol (E2) – function
Estradiol (E2) – deficiency
Estradiol (E2) – excess
Estradiol (E2) – sleep comfort
Estradiol (E2), best known as one of the estrogens, is another hormone described by experts collaborating with ONSEN® in response to requests from readers of the best sleep blog.

As with almost every hormone, even the slightest disturbance in estradiol (E2) levels can result in disruption of the entire hormonal system. Our biopsychosocial functioning throughout the day, as well as our ability to have comfortable and restorative sleep at night, depend on this system.

That is why it is essential not only to understand what estradiol (E2) is but also to know its effects. This knowledge allows us to anticipate the consequences of estradiol (E2) deficiency or excess and to identify potential symptoms of diseases early on.
Menopause, hormones, night sweats, hormonal disorders, estrogen

Estradiol (E2) – meaning

Estradiol (E2) is one of the most important hormones belonging to the group of estrogens. It is the most abundant hormone in this group in humans. It plays a crucial role in the regulation of developmental and physiological processes in women. Estradiol (E2) is mainly synthesized by the ovaries, but also by the adrenal glands and adipose tissue.

Furthermore, estradiol (E2) plays a significant role in the regulation of the menstrual cycle and in the development and maintenance of female characteristics. Moreover, estradiol (E2) directly affects metabolism, the skeletal system, blood vessels, and the nervous system. Additionally, estradiol regulates the functioning of the reproductive organs such as the uterus and breasts.

The normal range of estradiol (E2) in the blood varies depending on gender. In males, the normal range of estradiol (E2) is always from 25.8 pg/ml to 60.7 pg/ml. In boys, it ranges from 5 pg/ml to 20 pg/ml, while in girls, it should be from 6 pg/ml to 27 pg/ml3. The normal range of estradiol (E2) is different in adult females.
  • In the follicular phase (the first phase of the menstrual cycle), the normal range of estradiol (E2) is from 12.4 pg/ml to 233.0 pg/ml;
  • In the ovulatory phase (between the first and second phase of the menstrual cycle), the normal range of estradiol (E2) is from 41.0 pg/ml to 398.0 pg/ml;
  • In the luteal phase (the second phase of the menstrual cycle), the normal range of estradiol (E2) is from 22.3 pg/ml to 341.0 pg/ml;
  • In the first trimester of pregnancy, the normal range of estradiol (E2) is from 154.0 pg/ml to 3243 pg/ml;
  • In the second trimester of pregnancy, the normal range of estradiol (E2) is from 1561.0 pg/ml to 21,280 pg/ml;
  • In the third trimester of pregnancy, the normal range of estradiol (E2) is from 8525.0 pg/ml to as high as 30,000 pg/ml;
  • During menopause, the normal range of estradiol (E2) is up to 341 pg/ml.
Estradiol in pregnancy, menstruation, hormonal cycle, menstrual period

Estradiol (E2) – function

Orthopedic pillow for every position, sleeping during menopause, night sweats, night sweating

Estradiol (E2) – deficiency

A deficiency of estradiol (E2) can be associated with symptoms related to the reproductive system, where it is produced. The most commonly observed causes of estradiol (E2) deficiency include:
  • menopause;
  • chronic stress;
  • Turner syndrome;
  • polycystic ovary syndrome (PCOS);
  • ovarian tumor;
  • hypothyroidism;
  • imbalanced diet;
  • improper sleep hygiene;
  • chronic stress.
Sustained low levels of estradiol (E2) in the blood are not desirable. The most commonly reported effects of estradiol (E2) deficiency include:
  • hot flashes;
  • vaginal dryness;
  • osteoporosis;
  • chronic fatigue;
  • weight gain;
  • loss of libido;
  • mood disorders;
  • sleep disturbances.
Estradiol, low estradiol, sex hormones, menopause

Estradiol (E2) – excess

An excess of estradiol (E2) is most commonly associated with disorders of the hormonal system. The most frequently reported causes of estradiol (E2) excess include:
  • ovarian hyperactivity;
  • thyroid hyperactivity;
  • overweight;
  • obesity;
  • insulin resistance;
  • use of contraceptive pills containing estradiol (E2).
Sustained high levels of estradiol (E2) in the blood are not desirable. The most commonly reported effects of estradiol (E2) excess include:
  • menstrual disorders;
  • increased risk of breast cancer;
  • disorders of lipid metabolism;
  • sexual disorders;
  • mood disorders;
  • sleep disturbances.
Estradiol, high estradiol, estrogen, ovarian hormones, hormonal storm

Estradiol (E2) – sleep comfort

Collaborating with ONSEN®, Health and Rehabilitation Psychologist, Mateusz Nesterok, draws attention to the consequences of excess estradiol (E2). While estradiol (E2) is essential for life and plays a positive role, maintaining its optimal level is crucial for good health. Excess estradiol (E2) can cause disruptions in lipid metabolism and also affect mood and sleep. The consequences of excess estradiol (E2) can also include sexual disorders and increased risk of developing breast cancer in some women.

It is also pointed out that low levels of estradiol (E2) are not a desirable state for humans either. Concentrations of estradiol (E2) below normal can lead to loss of libido or chronic fatigue. Due to its association with the skeletal system, it can also be a factor in the development of osteoporosis. It also affects cognitive functions.

As scientific research indicates, estradiol (E2) plays a significant role in sleep quality. Its level is particularly important for women in the menopausal period who have undergone radical hormonal changes. Too low levels of estradiol (E2) can cause insomnia, while higher levels can increase the duration of REM sleep during menstruation.

Maintaining an optimal level of estradiol (E2) in the blood is supported by comfortable, healthy sleep. This requires having a functional mattress that provides ideal body support and spine support. Maintaining the physiological curvature of the spine during sleep, as well as allowing the body to fully relax, has a beneficial effect on all bodily systems, including the hormonal system.

ONSEN® offers the Osaka Air mattress, which is the most functional mattress available on the market. Its jobs to be done are to meet the users' needs and to effectively solve problems they may have. Thanks to this, it has become a cult product that fulfills all 10 basic mattress functionalities and allows for comfortable and healthy sleep. Moreover, like all ONSEN® products, the mattress is covered by even a 15-year warranty, as well as a program allowing for return within 100 days, minimizing the purchase risk to zero.

We also encourage you to explore other articles on the best sleep and health blog, as well as the Encyclopedia of Healthy Sleep prepared by the ONSEN® team of specialists. For those who care about spine health, we recommend a set of spine exercises prepared by our physiotherapist.
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FAQ: Estradiol (E2)

What is estradiol (E2) responsible for?

Estradiol (E2) is a natural estrogen hormone that plays a crucial role in regulating the development and function of female reproductive organs. Additionally, estradiol (E2) is responsible for controlling the menstrual cycle, breast development, maintaining bone density, and influencing many other processes in the body.

What are the effects of estradiol (E2) deficiency or low levels?

Estradiol (E2) deficiency can lead to various symptoms and consequences. In women, it can cause irregular menstrual cycles, fertility disorders, vaginal dryness, vaginal discharge, low bone mass (osteoporosis), and menopausal symptoms such as hot flashes and mood changes. In men, estradiol (E2) deficiency can affect sexual function, mood, and bone density.

What are the effects of estradiol (E2) excess or high levels?

High levels of estradiol (E2) can have different effects depending on gender and circumstances. In women, an excess of estradiol (E2) can lead to irregular or heavy menstrual bleeding, breast tenderness, bloating, mood swings, and increased risk of certain types of cancer. In men, excess estradiol (E2) can cause decreased libido, gynecomastia (enlarged breasts), and fertility problems.

How to increase estradiol (E2) secretion?

Increasing estradiol (E2) levels may be necessary in certain cases, such as hormonal disorders or menopause. In women, hormone replacement therapy (HRT) with estrogen may be used to increase estradiol (E2) levels. However, the decision regarding hormone therapy should be made by a doctor after a careful assessment of the benefits and risks for each patient.

How to decrease estradiol (E2) secretion?

Lowering estradiol (E2) levels may be necessary only in specific situations, such as certain cases of breast or endometrial cancer. In such cases, a doctor may recommend hormonal treatment aimed at pharmacologically reducing estradiol (E2) levels. Another method is surgical removal of the ovaries or pharmacological inhibition of estradiol (E2) production.

Contents
Estradiol (E2) – meaning
Estradiol (E2) – function
Estradiol (E2) – deficiency
Estradiol (E2) – excess
Estradiol (E2) – sleep comfort
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