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Somatotropin (GH) – significance, function, deficiency, excess

20 stycznia 2023
Somatotropin, GH, metabolism, somatotropin deficiency, somatotropin excess
Somatotropin (GH), also known as growth hormone, is another hormone described by experts collaborating with ONSEN® in response to requests from from readers of the best blog about sleep.

As with almost every hormone, even the slightest disruption in somatotropin (GH) levels can result in the dysregulation of the entire hormonal system. Our biopsychosocial functioning throughout the day and our ability to have comfortable and restorative sleep at night depend on this system.

That is why it is so important to know not only what somatotropin (GH) is, but also how it works. This allows us to predict the potential dangers of somatotropin (GH) deficiency or excess and to identify any potential symptoms of illness early on.
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Somatotropin (GH) – function

Somatotropin (GH), also known as growth hormone, is one of the most important hormones in the human body. It is produced by the anterior pituitary gland and is released in response to neurohormonal signals. The action of somatotropin (GH) is diverse and affects many processes in the body.

The synthesis of somatotropin (GH) is a complex process that is controlled by a series of regulatory factors. Growth hormone is produced as a precursor called somatoliberin, which is processed in the pituitary gland into the active form of somatotropin. The concentration of growth hormone in the blood is regulated in a pulsatile manner, with the highest levels occurring during sleep and adolescence.
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Somatotropin (GH) – action

Somatotropin (GH) plays a crucial role in regulating the growth and development of the body. It is responsible for tissue growth, protein synthesis, regeneration, and energy metabolism. In addition, the growth hormone also acts as a neuromodulator, influencing cognitive and emotional functions.
 

The action of somatotropin (GH) is closely related to the process of body growth. This hormone stimulates the growth of tissues, both muscular and skeletal, by increasing cell division and protein synthesis. Somatotropin (GH) also affects metabolism by increasing the release of fatty acids from adipose tissue and stimulating gluconeogenesis in the liver, which increases glucose levels in the blood.
 

The growth hormone also has an anabolic effect, increasing protein synthesis and decreasing protein catabolism, which promotes muscle mass growth. Additionally, somatotropin (GH) affects the body's water-electrolyte balance by increasing sodium and calcium retention while reducing potassium excretion.
 

In addition to regulating growth and metabolism, somatotropin also plays a role in neurocognitive processes. Somatotropin (GH) affects cognitive processes such as memory, learning, concentration, and attention. It also plays a crucial role in tissue growth and regeneration, making it an important hormone responsible for the development and functioning of the body during growth and later in adulthood.

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Somatotropin (GH) – deficiency

A deficiency of somatotropin (GH) can be associated with disorders of the pituitary gland, where it is produced, as well as other glands. The most commonly reported causes of somatotropin (GH) deficiency are:

  • pituitary hypofunction;
  • brain development disorders;
  • brain tumor;
  • head injuries.

Persistently low levels of somatotropin in the blood are not desirable. The most commonly reported effects of somatotropin (GH) deficiency are:

  • dwarfism;
  • delayed sexual development;
  • abdominal obesity;
  • dry skin;
  • rapid fatigue;
  • chronic fatigue;
  • difficulty concentrating;
  • sensory disturbances;
  • mood disorders;
  • sleep disorders.
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Somatotropin (GH) – excess

Excess somatotropin (GH) is most commonly associated with hormonal system disorders. The most frequently reported causes of excess somatotropin (GH) include:
  • pituitary gland hyperfunction;
  • brain tumors, especially pituitary adenomas.
Sustained high levels of somatotropin (GH) in the blood are not recommended. The most commonly reported effects of excess somatotropin (GH) are:
  • gigantism;
  • acromegaly;
  • body deformities;
  • bone and joint overgrowth;
  • enlargement of internal organs;
  • excessive hair growth;
  • increased sweating;
  • insulin resistance;
  • diabetes;
  • psychomotor agitation;
  • mood disorders;
  • sleep disorders.
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Somatotropin (GH) – sleep comfort

Cooperating with ONSEN® health and rehabilitation psychologist, Mateusz Nesterok, draws attention to the consequences of excess somatotropin (GH). While somatotropin (GH) is essential in life and plays a positive role, maintaining its optimal level is crucial for good health. Excess growth hormone in children can cause gigantism and acromegaly, while in adults it increases sweating and causes cognitive disorders. The consequences of excess somatotropin (GH) can also be mood disorders, as well as often diabetes and other metabolic disorders.
 

He points out that too low a level of growth hormone is also not a desirable state for humans. Somatotropin (GH) levels below normal also lead to mood disorders and negatively affect cognitive processes. Additionally, it causes the accumulation of fat tissue in the abdominal area. It also causes dwarfism and hinders and slows down sexual development.
 

As scientific research shows, somatotropin (GH) plays an important role in regulating the amount of REM sleep in humans. Supplementation of growth hormone during sleep prolongs it. This also results from the fact that somatotropin (GH) levels are related to dopamine and the entire cholinergic system in the human brain. Therefore, when assessing sleep disorders, hormone levels in the blood should also be taken into account.
 

Maintaining an optimal level of somatotropin (GH) in the blood is facilitated by comfortable, healthy sleep. This requires having a functional mattress that provides ideal body support and spinal support. Maintaining physiological spinal curves during sleep, as well as allowing the body to fully relax, has a beneficial effect on all its systems, including the hormonal system.
 

ONSEN® offers the Osaka Air mattress, which is the most functional mattress available on the market. It meets the needs of the most demanding consumers, meeting all 10 basic functionalities of the mattress, as well as being a first-class medical device.

All ONSEN® products are subject to a 15-year warranty, as well as a 100-day return program, which minimizes the risk of purchase to zero.

We also encourage you to read the other articles on the best sleep and health blog, as well as the Encyclopedia of Healthy Sleep prepared by the team of ONSEN® specialists.

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FAQ: Somatotropin (GH)

What is somatotropin (GH) responsible for?

Somatotropin (GH) is primarily responsible for growth. Its main role is to stimulate tissue growth, protein synthesis, and body regeneration. It also affects the energy metabolism in humans. Additionally, somatotropin (GH) acts as a neuromodulator shaping cognitive and emotional functions.

What are the effects of somatotropin (GH) deficiency or low levels?

Somatotropin (GH) deficiency during adolescence can result in dwarfism and underdeveloped sexual organs. Meanwhile, low levels of somatotropin (GH) in teenagers and adults are manifested as faster fatigue and chronic tiredness. In addition, its deficiency can lead to abdominal obesity and mental disorders.

What are the effects of somatotropin (GH) excess or high levels?

The primary effect of somatotropin (GH) excess or high levels during adolescence is the possibility of acromegaly and gigantism. Additionally, high levels of somatotropin (GH) cause body deformities, bone and joint overgrowth, and enlargement of internal organs. Too high a concentration of growth hormone in the blood often leads to insulin resistance and diabetes.

How to increase somatotropin (GH) secretion?

Somatotropin (GH) secretion can be increased by administering pharmacological agents based on the recommendations of a specialist doctor. Abnormal hormone levels in the blood require an endocrinological consultation. However, the level of growth hormone in the blood also increases during the performance of intense strength and endurance exercises.

How to decrease somatotropin (GH) secretion?

Somatotropin (GH) secretion can be reduced by administering pharmacological agents based on the recommendations of a specialist doctor. Abnormal hormone levels in the blood require an endocrinological consultation. Usually, patients are given somatostatin, which decreases the level of growth hormone in the blood by acting antagonistically.

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